Research > Targeting cancer
Polymer-drug conjugates to target specific markers in the tumor microenvironment for cancer therapy
Polymer–drug conjugates that can actively target the tumor microenvironment have emerged as an attractive technology for improving the therapeutic efficacy of cytotoxic drugs. In addition to the drug or imaging molecules, these polymers possess new cell targeting ligands specific for markers uniquely expressed or over-expressed on cells at the disease site. Several polymers made from different materials have been designed and evaluated by our laboratory to target different cell types in the tumor microenvironment.
Design of polymer-drug conjugates that selectively target E-selectin expressed by activated endothelial cells in angiogenic vasculature
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Our tumor vasculature-targeted technology was licensed to Vaxil Bio Pharmaceutics for further development. Read more
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