Research > Gene delivery
Dendritic cells targeted polymeric DNA-delivery systems (polyplexes) for cancer immunotherapy
The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Existing nucleic-acid delivery platforms suffer from poor cellular targeting, rapid clearance, and off-target toxicity.
We developed dendritic-cell–targeted polymeric DNA-delivery systems (polyplexes) that efficiently load, protect, and safely deliver DNA to dendritic cells, enabling robust gene expression for cancer immunotherapy
Mannose-decorated PEI/DNA polyplexes target DCs in draining lymph nodes via mannose receptor (CD206) binding. Raviv L. et al., Mol. Pharmaceutics, 2015
New polymers for gene silencing
Our octaarginine (R8)-grafted polymers form stable siRNA polyplexes with enhanced uptake and endosomolytic activity, leading to robust gene silencing in cancer cells
Octaarginine (R8)-grafted polymers for siRNA delivery and gene silencing in cancer cells. Golan M. et al., Eur. J. Pharm. Biopharm., 2016