Selected Publications​

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  1. Kopansky-Groisman E., Kogan-Zviagin I., Sella-Tavor O., Oron-Herman M., and David A., Near-Infrared Fluorescent Activated Polymeric Probe for Imaging Intraluminal Colorectal Cancer Tumors, Biomacromolecules, 2019 Link

  2. Zaiden M., Ruetter, Shpirt L., M., Venture  Y.,  Feinshtein V., David A., CD44-targeted polymer-paxlitaxel conjugates to control the spread and growth of metastatic tumors. Mol Pharm., 15, 3690-3699, 2018. Link

  3. Tsoref O., Tyomkin D., Amit U, Landa N., Rosenboim-Cohen O., Kain D., Golan M., David A., Leor, J., E-selectin-targeted nano-sized polymer attenuates atherosclerosis, vascular inflammation, and adverse cardiac remodeling, J. Control. Release., 288, 136-147. 2018. Link

  4. David, A., Peptide ligand-modified nanomedicines for targeting cells at the tumor microenvironment. Adv Drug Deliv Rev. 119:120-142, 2017. Link
  5. Zaiden M., Feinshtein V., David A., Inhibition of CD44v3 and CD44v6 function blocks tumor invasion and metastatic colonization, J. Control. Release., 2017. Link
  6. Golan M., Feinshtein V., David A., Conjugates of HA2 with octaarginine-grafted HPMA copolymer offer effective siRNA delivery and gene silencing in cancer cells. Eur J Pharm Biopharm. 109:103-112, 2016. Link
  7. Shamay Y., Golan M., Tyomkin D., David A., Assessing the therapeutic efficacy of VEGFR-1-targeted polymer drug conjugate in mouse tumor models. J. Control. Release., 229, 192-9, 2016. Link
  8. Golan M, Feinshtein V, Polyak D, Scomparin A, Satchi-Fainaro R, David A., Inhibition of gene expression and cancer cell migration by CD44v3/6-targeted polyion complexes. Bioconjug. Chem. 27, 947-60, 2016. Link
  9. David A. and Golani-Armon A. “Polymer-based DNA delivery systems for cancer immunotherapy”. In Howard K., Vorup-Jensen T. and Peer D. (Eds) “Nanomedinice”. CRS Book Series Advances in Delivery Science and Technology.  Springer. 2016. Link
  10. Shamay Y., Raviv L., Golan M., Voronov E., Apte R.N., David A., Inhibition of primary and metastatic tumors in mice by E-selectin-targeted polymer–drug conjugate. J. Control. Release., 217, 102-112, 2015. Link
  11. Golani-Armon, A., Golan, M., Shamay, Y., Raviv, L., David, A., DC3-Decorated Polyion Complexes for Targeted Gene Delivery into Dendritic Cells, Bioconj. Chem., 26, 213-24, 2015. Link
  12. Raviv, L., Jaron-Mendelson, M. David, A., Mannosylated polyion for in vivo gene deliverinto CD11c+ dendritic cells. Mol Pharm., 12, 453-462, 2015. Link
  13. Kogan-Zviagin, I., Shamay, Y., Nissan, A., Sella-Tavor, O., Golan, M., David, A. Intra-colonic administration of a polymer-bound NIRF probe for improved colorectal cancer detection during colonoscopy. J. Control. Release, 192, 182-191, 2014. Link
  14. Yishay-Safranchik, E., Golan, M., David, A. Controlled release of doxorubicin and Smac-derived proapoptotic peptide from self-assembled KLD-based peptide hydrogels. Polymers for Advanced Technologies, 25, 539-544, 2014. Link
  15. Shamay, Y, Shpirt, L, Ashkenasy, G, David, A. Complexation of Cell-Penetrating Peptide-Polymer Conjugates with Polyanions Controls Cells Uptake of HPMA Copolymers and Anti-tumor Activity. Pharm Res 3, 768-79, 2014. Link
  16. Journo-Gershfeld, G. Israeli Kapp, D. Shamay, Y. Kopecek, J., David, A. Hyaluronan Oligomers-HPMA Copolymer Conjugates for Targeting Paclitaxel to CD44-overexpressing Ovarian Carcinoma. Pharm. Res.  29,1121-33, 2012. Link
  17. Kopansky, E. Shamay, Y., David, A. Peptide-directed HPMA copolymer-DOX conjugates as targeted therapeutics for colorectal cancer. J Drug Target 19, 933-943, 2011. Link
  18. Shamay, Y., Adar, L., Ashkenasy, G., David, A. Light Induced Drug Delivery into Cancer Cells, Biomaterials, 32, 1377-86, 2011. Link
  19. Adar, L., Shamay, Y., Journo, G., David, A. Pro-apoptotic Peptide-Polymer Conjugates to Induce Mitochondrial-Dependent Cell Death. Polymers for Advanced Technologies, 22, 199-208, 2011. Link
  20. David, A., Carbohydrate-Based Biomedical Copolymers for Targeted Delivery of Anticancer Drugs, Israel Journal of Chemistry, 50, 204-219, 2010. Link
  21. Mendelson, M., Tekoah, Y., Zilka A., Gershoni-Yahalom, O., Gazit , R.,  Achdut, H., Bovin , N.V., Meningher, T., Mandelboim, M., Mandelboim , O., David, A., Porgador, A., NKp46 O-glycan sequences that are involved in the interaction with hemagglutinin type 1 of influenza virus. J Virol., 84, 3789-97, 2010.  Link
  22. Shamay, Y., Paulin, D., Ashkenasy, G., David, A., Multivalent display of quinic acid based ligands for targeting E-selectin expressing cells. J Med Chem. 52, 5906-15, 2009. Link
  23. Shamay, Y., Paulin, D., Ashkenasy, G., David, A. E-selectin Binding Peptide-Polymer-Drug Conjugates and Their selective Cytotoxicity Against Vascular Endothelial Cells. Biomaterials, 30, 6460-8, 2009. Link

Ben-Gurion University of the Negev, Israel

Contact me - ayeletda@bgu.ac.il