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Selected Publications​

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  1. Milošević, N. Rütter, M., Ventura, Y., Feinshtein, V. and David, A. Targeted Polymer-peptide Conjugate for E-selectin Blockade in Renal Injury, Pharmaceutics, 17,1,82, 2025

  2. Srivastava P., Rütter M., Gover A. M., Ventura Y., and David A., Dendritic cell-targeted nanoparticles to simultaneously block PD-L1 pathways and boost antigen presentation for T cell activation,  Applied Materials and Interfaces, 16, 53577-53590, 2024

  3. Rütter, M., Milošević, N. Ventura, Y., Kezerle, Y., Feinshtein, V. and David, A. Targeting E-selectin in the tumor microenvironment for the treatment of established colorecta cancer liver metastases, Nano Today, 55, 102182, 2024

  4. Milošević, N., Rütter, M. and David, A., Endothelial Cell Adhesion Molecules-(un)Attainable Targets for Nanomedicines, Frontiers in medical technology. 4, 22, 846065, 2022

  5. Rütter M., Milošević N. and David A., Say No To Drugs: Bioactive macromolecular therapeutics without conventional drugs, J. Control. Release, 10;330:1191-1207, 2021.

  6. Milošević N., Rütter M., Ventura Y., Kezerle Y., Feinstein V., and David A., Attenuation of Neutrophil-Mediated Liver Injury in Mice by Drug-free E-Selectin Binding Polymer,  J. Control. Release, 319, 475-486, 2020. 

  7. Kopansky-Groisman E., Kogan-Zviagin I., Sella-Tavor O., Oron-Herman M., and David A., Near-Infrared Fluorescent Activated Polymeric Probe for Imaging Intraluminal Colorectal Cancer Tumors, Biomacromolecules, 2019 Link

  8. Zaiden M., Ruetter, Shpirt L., M., Venture  Y.,  Feinshtein V., David A., CD44-targeted polymer-paxlitaxel conjugates to control the spread and growth of metastatic tumors. Mol Pharm., 15, 3690-3699, 2018. Link

  9. Tsoref O., Tyomkin D., Amit U, Landa N., Rosenboim-Cohen O., Kain D., Golan M., David A., Leor, J., E-selectin-targeted nano-sized polymer attenuates atherosclerosis, vascular inflammation, and adverse cardiac remodeling, J. Control. Release., 288, 136-147. 2018. Link

  10. David, A., Peptide ligand-modified nanomedicines for targeting cells at the tumor microenvironment. Adv Drug Deliv Rev. 119:120-142, 2017. Link
  11. Zaiden M., Feinshtein V., David A., Inhibition of CD44v3 and CD44v6 function blocks tumor invasion and metastatic colonization, J. Control. Release., 2017. Link
  12. Golan M., Feinshtein V., David A., Conjugates of HA2 with octaarginine-grafted HPMA copolymer offer effective siRNA delivery and gene silencing in cancer cells. Eur J Pharm Biopharm. 109:103-112, 2016. Link
  13. Shamay Y., Golan M., Tyomkin D., David A., Assessing the therapeutic efficacy of VEGFR-1-targeted polymer drug conjugate in mouse tumor models. J. Control. Release., 229, 192-9, 2016. Link
  14. Golan M, Feinshtein V, Polyak D, Scomparin A, Satchi-Fainaro R, David A., Inhibition of gene expression and cancer cell migration by CD44v3/6-targeted polyion complexes. Bioconjug. Chem. 27, 947-60, 2016. Link
  15. David A. and Golani-Armon A. “Polymer-based DNA delivery systems for cancer immunotherapy”. In Howard K., Vorup-Jensen T. and Peer D. (Eds) “Nanomedinice”. CRS Book Series Advances in Delivery Science and Technology.  Springer. 2016. Link
  16. Shamay Y., Raviv L., Golan M., Voronov E., Apte R.N., David A., Inhibition of primary and metastatic tumors in mice by E-selectin-targeted polymer–drug conjugate. J. Control. Release., 217, 102-112, 2015. Link
  17. Golani-Armon, A., Golan, M., Shamay, Y., Raviv, L., David, A., DC3-Decorated Polyion Complexes for Targeted Gene Delivery into Dendritic Cells, Bioconj. Chem., 26, 213-24, 2015. Link
  18. Raviv, L., Jaron-Mendelson, M. David, A., Mannosylated polyion for in vivo gene deliverinto CD11c+ dendritic cells. Mol Pharm., 12, 453-462, 2015. Link
  19. Kogan-Zviagin, I., Shamay, Y., Nissan, A., Sella-Tavor, O., Golan, M., David, A. Intra-colonic administration of a polymer-bound NIRF probe for improved colorectal cancer detection during colonoscopy. J. Control. Release, 192, 182-191, 2014. Link
  20. Yishay-Safranchik, E., Golan, M., David, A. Controlled release of doxorubicin and Smac-derived proapoptotic peptide from self-assembled KLD-based peptide hydrogels. Polymers for Advanced Technologies, 25, 539-544, 2014. Link
  21. Shamay, Y, Shpirt, L, Ashkenasy, G, David, A. Complexation of Cell-Penetrating Peptide-Polymer Conjugates with Polyanions Controls Cells Uptake of HPMA Copolymers and Anti-tumor Activity. Pharm Res 3, 768-79, 2014. Link
  22. Journo-Gershfeld, G. Israeli Kapp, D. Shamay, Y. Kopecek, J., David, A. Hyaluronan Oligomers-HPMA Copolymer Conjugates for Targeting Paclitaxel to CD44-overexpressing Ovarian Carcinoma. Pharm. Res.  29,1121-33, 2012. Link
  23. Kopansky, E. Shamay, Y., David, A. Peptide-directed HPMA copolymer-DOX conjugates as targeted therapeutics for colorectal cancer. J Drug Target 19, 933-943, 2011. Link
  24. Shamay, Y., Adar, L., Ashkenasy, G., David, A. Light Induced Drug Delivery into Cancer Cells, Biomaterials, 32, 1377-86, 2011. Link
  25. Adar, L., Shamay, Y., Journo, G., David, A. Pro-apoptotic Peptide-Polymer Conjugates to Induce Mitochondrial-Dependent Cell Death. Polymers for Advanced Technologies, 22, 199-208, 2011. Link
  26. David, A., Carbohydrate-Based Biomedical Copolymers for Targeted Delivery of Anticancer Drugs, Israel Journal of Chemistry, 50, 204-219, 2010. Link
  27. Mendelson, M., Tekoah, Y., Zilka A., Gershoni-Yahalom, O., Gazit , R.,  Achdut, H., Bovin , N.V., Meningher, T., Mandelboim, M., Mandelboim , O., David, A., Porgador, A., NKp46 O-glycan sequences that are involved in the interaction with hemagglutinin type 1 of influenza virus. J Virol., 84, 3789-97, 2010.  Link
  28. Shamay, Y., Paulin, D., Ashkenasy, G., David, A., Multivalent display of quinic acid based ligands for targeting E-selectin expressing cells. J Med Chem. 52, 5906-15, 2009. Link
  29. Shamay, Y., Paulin, D., Ashkenasy, G., David, A. E-selectin Binding Peptide-Polymer-Drug Conjugates and Their selective Cytotoxicity Against Vascular Endothelial Cells. Biomaterials, 30, 6460-8, 2009. Link
  30. David, A., Kopeckova, P., Rubinstein, A. and Kopecek, J., Design of Multivalent Glycoside Ligand for Selective Targeting of HPMA Copolymer-Doxorubicin Conjugates to Human Colon Cancer Cells, Eur. J. Cancer, 40: 148-57, 2004.
  31. Rubinstein, A., David, A., Kopeckova, P., and Kopecek, J., Specific attachment of a novel acrylo-saccharide polymer to colon cancer cell lines. Israel Medical Association Journal., 5, 606, 2003.
  32. David , A., Kopeckova, P., Kopecek, J. and Rubinstein, A., The Role of Galactose, Lactose and the Galactose Valency in the Biorecognition of HPMA Copolymer by Human Colon Adenocarcinoma Cells. Pharm. Res., 19, 1114-1122, 2002
  33. David, A., Kopeckova, P., Rubinstein, A. and Kopecek, J.,  Enhanced Biorecognition and Internalization of HPMA Copolymers Containing Multi- or Multivalent Carbohydrate Side-Chains by Human Hepatocarcinoma Cells,  Bioconj. Chem., 12, 890-899, 2001.
  34. Rubinstein, A., Tirosh, B., Baluom, M., Nassar, T., David, A., Gliko-Kabir, I., Radai, R. and FriedmanC, M. The Rationale for Peptide Drugs Delivery to the Colon and the Potential of Polymeric Carriers as Effective Tools. J. Control. Release, 46: 59-73, 1997.
  35. David , A., Yagen, B., Sintov, A. and Rubinstein, A., Acrylic Polymers For Colon-Specific Drug Delivery. s.t.p. Pharm.Sci., 6: 546-554, 1997.
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