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Selected Publications​

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​​​2026

  • Teboul I, Shlush N, Droby M, Ventura Y, Levine, R.A., David, Polymeric Probe for Sensitive Diagnosis of Serum Endothelial Cell Adhesion Molecules in Rheumatic Heart Disease. ACS Sensors. Accepted.

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2025

  • Milošević N, Rütter M, Ventura Y, Feinshtein V, David A. Targeted Polymer-Peptide Conjugates for E-Selectin Blockade in Renal Injury. Pharmaceutics. 2025 Jan 9;17(1):82. doi: 10.3390/pharmaceutics17010082. 

  • Srivastava P, Rütter M, Antoniraj GM, Ventura Y, David A. Mesoporous Silica Nanoparticles with Extra-Large Pores for Boosting Antigen Presentation and PD-L1 Immune Checkpoint Blockade. ACS Appl Bio Mater. 2025 Nov 17;8(11):9864-9874. doi: 10.1021/acsabm.5c01211.

 

2024

  • Srivastava P, Rütter M, Antoniraj G M, Ventura Y, David A. Dendritic Cell-Targeted Nanoparticles Enhance T Cell Activation and Antitumor Immune Responses by Boosting Antigen Presentation and Blocking PD-L1 Pathways. ACS Appl Mater Interfaces. 2024 Oct 9;16(40):53577-53590. doi: 10.1021/acsami.4c12821. 

  • Rütter, M., Milošević, N. Ventura, Y., Kezerle, Y., Feinshtein, V. and David, A. Targeting E-selectin in the tumor microenvironment for the treatment of established colorecta cancer liver metastases, Nano Today, 55, 102182, 2024

 

2022​

  • Milošević N, Rütter M, David A. Endothelial Cell Adhesion Molecules- (un)Attainable Targets for Nanomedicines. Front Med Technol. 2022 Apr 7;4:846065. doi: 10.3389/fmedt.2022.846065. 

 

2021

  • Rütter M., Milošević N. and David A., Say No To Drugs: Bioactive macromolecular therapeutics without conventional drugs, J. Control. Release, 10;330:1191-1207, 2021.

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2020

  • Milošević N., Rütter M., Ventura Y., Kezerle Y., Feinstein V., and David A., Attenuation of Neutrophil-Mediated Liver Injury in Mice by Drug-free E-Selectin Binding Polymer,  J. Control. Release, 319, 475-486, 2020. 

 

2019

  • Kopansky-Groisman E., Kogan-Zviagin I., Sella-Tavor O., Oron-Herman M., and David A., Near-Infrared Fluorescent Activated Polymeric Probe for Imaging Intraluminal Colorectal Cancer Tumors, Biomacromolecules, 2019 Link

 

2018

  • Zaiden M., Ruetter, Shpirt L., M., Venture  Y.,  Feinshtein V., David A., CD44-targeted polymer-paxlitaxel conjugates to control the spread and growth of metastatic tumors. Mol Pharm., 15, 3690-3699, 2018. Link

  • Tsoref O., Tyomkin D., Amit U, Landa N., Rosenboim-Cohen O., Kain D., Golan M., David A., Leor, J., E-selectin-targeted nano-sized polymer attenuates atherosclerosis, vascular inflammation, and adverse cardiac remodeling, J. Control. Release., 288, 136-147. 2018. Link

 

2017

  • David, A., Peptide ligand-modified nanomedicines for targeting cells at the tumor microenvironment. Adv Drug Deliv Rev. 119:120-142, 2017. Link
  • Zaiden M., Feinshtein V., David A., Inhibition of CD44v3 and CD44v6 function blocks tumor invasion and metastatic colonization, J. Control. Release., 2017. Link​

 

2016

  • Golan M., Feinshtein V., David A., Conjugates of HA2 with octaarginine-grafted HPMA copolymer offer effective siRNA delivery and gene silencing in cancer cells. Eur J Pharm Biopharm. 109:103-112, 2016. Link
  • Shamay Y., Golan M., Tyomkin D., David A., Assessing the therapeutic efficacy of VEGFR-1-targeted polymer drug conjugate in mouse tumor models. J. Control. Release., 229, 192-9, 2016. Link
  • Golan M, Feinshtein V, Polyak D, Scomparin A, Satchi-Fainaro R, David A., Inhibition of gene expression and cancer cell migration by CD44v3/6-targeted polyion complexes. Bioconjug. Chem. 27, 947-60, 2016. Link
  • David A. and Golani-Armon A. “Polymer-based DNA delivery systems for cancer immunotherapy”. In Howard K., Vorup-Jensen T. and Peer D. (Eds) “Nanomedinice”. CRS Book Series Advances in Delivery Science and Technology.  Springer. 2016. Link

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2015

  • Shamay Y., Raviv L., Golan M., Voronov E., Apte R.N., David A., Inhibition of primary and metastatic tumors in mice by E-selectin-targeted polymer–drug conjugate. J. Control. Release., 217, 102-112, 2015. Link
  • Golani-Armon, A., Golan, M., Shamay, Y., Raviv, L., David, A., DC3-Decorated Polyion Complexes for Targeted Gene Delivery into Dendritic Cells, Bioconj. Chem., 26, 213-24, 2015. Link
  • Raviv, L., Jaron-Mendelson, M. David, A., Mannosylated polyion for in vivo gene deliverinto CD11c+ dendritic cells. Mol Pharm., 12, 453-462, 2015. Link

 

2014

  • Kogan-Zviagin, I., Shamay, Y., Nissan, A., Sella-Tavor, O., Golan, M., David, A. Intra-colonic administration of a polymer-bound NIRF probe for improved colorectal cancer detection during colonoscopy. J. Control. Release, 192, 182-191, 2014. Link
  • Yishay-Safranchik, E., Golan, M., David, A. Controlled release of doxorubicin and Smac-derived proapoptotic peptide from self-assembled KLD-based peptide hydrogels. Polymers for Advanced Technologies, 25, 539-544, 2014. Link
  • Shamay, Y, Shpirt, L, Ashkenasy, G, David, A. Complexation of Cell-Penetrating Peptide-Polymer Conjugates with Polyanions Controls Cells Uptake of HPMA Copolymers and Anti-tumor Activity. Pharm Res 3, 768-79, 2014. Link

 

2012

  • Journo-Gershfeld, G. Israeli Kapp, D. Shamay, Y. Kopecek, J., David, A. Hyaluronan Oligomers-HPMA Copolymer Conjugates for Targeting Paclitaxel to CD44-overexpressing Ovarian Carcinoma. Pharm. Res.  29,1121-33, 2012. Link

 

2011

  • Kopansky, E. Shamay, Y., David, A. Peptide-directed HPMA copolymer-DOX conjugates as targeted therapeutics for colorectal cancer. J Drug Target 19, 933-943, 2011. Link
  • Shamay, Y., Adar, L., Ashkenasy, G., David, A. Light Induced Drug Delivery into Cancer Cells, Biomaterials, 32, 1377-86, 2011. Link
  • Adar, L., Shamay, Y., Journo, G., David, A. Pro-apoptotic Peptide-Polymer Conjugates to Induce Mitochondrial-Dependent Cell Death. Polymers for Advanced Technologies, 22, 199-208, 2011. Link

 

2010

  • David, A., Carbohydrate-Based Biomedical Copolymers for Targeted Delivery of Anticancer Drugs, Israel Journal of Chemistry, 50, 204-219, 2010. Link
  • Mendelson, M., Tekoah, Y., Zilka A., Gershoni-Yahalom, O., Gazit , R.,  Achdut, H., Bovin , N.V., Meningher, T., Mandelboim, M., Mandelboim , O., David, A., Porgador, A., NKp46 O-glycan sequences that are involved in the interaction with hemagglutinin type 1 of influenza virus. J Virol., 84, 3789-97, 2010.  Link

 

2009

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  • Shamay, Y., Paulin, D., Ashkenasy, G., David, A., Multivalent display of quinic acid based ligands for targeting E-selectin expressing cells. J Med Chem. 52, 5906-15, 2009. Link
  • Shamay, Y., Paulin, D., Ashkenasy, G., David, A. E-selectin Binding Peptide-Polymer-Drug Conjugates and Their selective Cytotoxicity Against Vascular Endothelial Cells. Biomaterials, 30, 6460-8, 2009. Link

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2004

  • ​David, A., Kopeckova, P., Rubinstein, A. and Kopecek, J., Design of Multivalent Glycoside Ligand for Selective Targeting of HPMA Copolymer-Doxorubicin Conjugates to Human Colon Cancer Cells, Eur. J. Cancer, 40: 148-57, 2004.

 

2003

  • Rubinstein, A., David, A., Kopeckova, P., and Kopecek, J., Specific attachment of a novel acrylo-saccharide polymer to colon cancer cell lines. Israel Medical Association Journal., 5, 606, 2003.

 

2002

  • David , A., Kopeckova, P., Kopecek, J. and Rubinstein, A., The Role of Galactose, Lactose and the Galactose Valency in the Biorecognition of HPMA Copolymer by Human Colon Adenocarcinoma Cells. Pharm. Res., 19, 1114-1122, 2002

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2001

  • David, A., Kopeckova, P., Rubinstein, A. and Kopecek, J.,  Enhanced Biorecognition and Internalization of HPMA Copolymers Containing Multi- or Multivalent Carbohydrate Side-Chains by Human Hepatocarcinoma Cells,  Bioconj. Chem., 12, 890-899, 2001.

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1997

  • Rubinstein, A., Tirosh, B., Baluom, M., Nassar, T., David, A., Gliko-Kabir, I., Radai, R. and FriedmanC, M. The Rationale for Peptide Drugs Delivery to the Colon and the Potential of Polymeric Carriers as Effective Tools. J. Control. Release, 46: 59-73, 1997.
  • David , A., Yagen, B., Sintov, A. and Rubinstein, A., Acrylic Polymers For Colon-Specific Drug Delivery. s.t.p. Pharm.Sci., 6: 546-554, 1997.
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